The risk of gastrointestinal bleed, myocardial infarction, and newly diagnosed hypertension in users of meloxicam, diclofenac, naproxen, and piroxicam.

摘要: Study Objective. To obtain formally quantified data on the relation of meloxicam to newly diagnosed gastrointestinal problems, myocardial infarction, or treated hypertension. Design. Nested case-control study. Setting. United Kingdom-based General Practice Research Database. Patients. Patients who received prescriptions for meloxicam, diclofenac, naproxen, piroxicam formed study population. Cases were people developed hypertension. Measurements and Main Results. Relative risk estimates developing outcomes provided each nonsteroidal antiinflammatory drug (NSAID), with diclofenac as reference drug. In no instance was associated an increased a outcome. Conclusion. Compared other NSAIDs, not materially any outcomes. This provides reassurance those prescribing this newer class NSAIDs.