Comparison of the effect of intra‐tendon applications of recombinant human platelet‐derived growth factor‐BB, platelet‐rich plasma, steroids in a rat achilles tendon collagenase model

摘要: This study compared the effect of intra-tendon (IT) delivery recombinant human platelet-derived growth factor-BB (rhPDGF-BB), platelet-rich plasma (PRP) and corticosteroids in a rat tendinopathy model. Seven days after collagenase induction tendinopathy, 30-µl IT injection was administered. Treatments included: saline; 3 µg rhPDGF-BB; 10 PRP; 300 triamcinolone acetonide (TCA). Outcomes were assessed 7 21 treatment. All groups exhibited good to excellent repair. Relative saline, cell proliferation increased 65% rhPDGF-BB group decreased 74% TCA group; inflammation group. At days, maximum load-to-failure relative PRP, (p < 0.025). On day 21, load-to-rupture 0.035) saline 0.027). Stiffness 0.038). Histology demonstrated similar repair all groups. PRP did not improve mechanical properties saline. Injections (3 µg) stiffness (10 controls commonly used treatments. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:145-150, 2014.