Snail is required for transforming growth factor-β-induced epithelial–mesenchymal transition by activating PI3 kinase/Akt signal pathway
作者： Hee Jun Cho , Kyoung Eun Baek , Shizuya Saika , Moon-Jin Jeong , Jiyun Yoo
DOI: 10.1016/J.BBRC.2006.12.035
关键词:
摘要: Lens epithelial cells undergo epithelial-mesenchymal transition (EMT) after injury as in cataract extraction, leading to fibrosis of the lens capsule. We have previously shown that EMT primary vitro depends on TGF-beta expression and more specifically, signaling via Smad3. In this report, we suggest phosphatidylinositol 3-OH kinase (PI3K)/Akt is also necessary for TGF-beta-induced by showing LY294002, an inhibitor p110 catalytic subunit PI3K, blocked alpha-smooth muscle actin (alpha-SMA) morphological changes. identify Snail effector EMT. has been be a mediator during metastasis cancer. show immediate-early response gene proximal promoter activated through action Smad2, 3, 4. antisense inhibition blocks furthermore Akt activation. All these findings participates acting upstream
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