Antimicrobial quinolone thioureas
作者： Ronald Eugene White , Thomas Prosser Demuth
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摘要: Antimicrobial quinolone thiourea compounds of general formula (I), wherein (1) A?1, A2, A3, R1, R3, R4, and R6? form any a variety related heterocyclic structures similar to those known in the art have antimicrobial activity; (2) R1 is X, R3 or both R?1 R3? are X; X -R?15-N(R16)(R17) -R15-R18-N(R19)(R17?), where (a) R15 nil, alkyl, carbocyclic ring, ring; R16 hydrogen; alkyl; alkenyl; (3) when R?15-N(R16)(R17), R15? may together comprise ring including nitrogen atom which R?15 R16? bonded; (b) R17 C(=S)-NR20R21; R20 hydrogen, alkenyl, R?21 N(R20)(R20); R21?, with they bonded, (c) R18) R19 R?18 R19? pharmaceutically-acceptable salts biohydrolyzable esters thereof, hydrates thereof.
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