Clostridium botulinumtype C produces a novel ADP-ribosyltransferase distinct from botulinum C2 toxin
作者： Klaus Aktories , Ulrich Weller , Gursharan S. Chhatwal
DOI: 10.1016/0014-5793(87)81566-1
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摘要: Abstract The culture medium of certain strains Clostridium botulinum type C contains two separable ADP-ribosyltransferases. Besides the ADP-ribosylation actin due to C2 I toxin, a second microbial enzyme causes mono-ADP-ribosylation eukaryotic protein with molecular mass about 20 kDa found in platelets, neuroblastoma × glioma hybrid cells, S49 lymphoma chick embryo fibroblasts and sperm. substrate is inactivated by heating trypsin treatment. In contrast, novel ADP-ribosyltransferase, which can be separated DEAE-Sephadex chromatography, largely resistant short term digestion.
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