Restenosis trials suggest role for remodeling.

摘要: ABSTRACT CONTROLLED TRIALS are causing researchers to rethink restenosis.The reclogging of arteries that have been cleared with balloon angioplasty or a similar procedure vexes about one third the 350 000 more patients who undergo such procedures in United States each year. Traditional thought and many failed therapeutic approaches based on notion merely return plaque, intimal hyperplasia, is responsible."We had several dozen new therapies introduced enabling clinicians obtain same unsatisfactory results 10 years ago but by greater variety costly methods," says Martin Leon, MD, director cardiovascular research at Washington (DC) Hospital Center.Controlled trials these drugs revealing reducing plaque does not necessarily reduce restenosis. Animal studies suggest amount hyperplasia forms after explains only fraction How