Bacterial Activation of Mucosal Cytokine Production

摘要: Publisher Summary Epithelial cells are the target of attaching microorganisms in lumen and mediators from mucosal environment, as such essential for outcome cross-talk between bacteria their hosts. Pathogens express virulence factors that enable them to overcome defenses tilt balance favor. The pathogens use specific adherence localize site infection; they secrete toxins trigger changes barrier cross mucosa with help invasion factors. Inflammation is a key very early steps pathogenesis infections, can act by directly triggering inflammatory processes mucosa. symptoms signs acute UTI attributable response induce when enter urinary tract. There elevated temperature, an acute-phase serum (C-reactive protein, CRP; erythrocyte sedimentation rate, ESR), local urine, immune dominated s-IgA antibodies. These host parameters suggested produced cytokines infection, these were involved disease. This chapter reviews summarizes some aspects studies on cytokine responses bacterial infection.