MicroRNA-183 suppresses retinoblastoma cell growth, invasion and migration by targeting LRP6.
作者： Jianwen Wang , Xiaochun Wang , Zhongji Li , Hongtao Liu , Yan Teng
DOI: 10.1111/FEBS.12659
关键词:
摘要: Our study demonstrates the downregulation of microRNA-183 (miR-183) in retinoblastoma (RB) tissues and RB cell lines compared with normal retinal tissues. The ectopic expression miR-183 Y79, SO-RB50 WERI-RB1 suppresses viability, migration invasion. Furthermore, Wnt co-receptor low-density lipoprotein receptor-related protein 6 (LRP6) was identified as a new target miR-183, restoration LRP6 rescues effects induced by cells. These results indicate that targets downregulates growth, invasion
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