Chronic exposure to aluminum and melatonin through the diet: Neurobehavioral effects in a transgenic mouse model of Alzheimer disease

摘要: Aluminum (Al) is a known neurotoxic element involved in the etiology of some serious neurodegenerative disorders such as Alzheimer disease (AD). Antioxidants like melatonin might protect neurons against damage produced AD. The APPSWE (Tg2576) transgenic mouse one most used animal models developed to mimic AD damage. In present study, wild type and Tg2576 mice were orally exposed during 14 months Al, melatonin, citric acid, well all possible combinations between them. At 17 age, evaluated for behavior using open-field test Morris water maze. Transgenic animals only Al plus acid showed good acquisition. No effects on acquisition maze observed mice. With respect retention task, animals, Control long term retention. Melatonin improved learning spatial memory Al-exposed