Anticlastogenic effect of flavonoids against mutagen-induced micronuclei in mice
作者： M.Y. Heo , K.S. Yu , K.H. Kim , H.P. Kim , W.W. Au
DOI: 10.1016/0027-5107(92)90008-P
关键词:
摘要: 14 flavonoids, including flavone and flavonol derivatives, were tested for their anticlastogenic effect against induction of micronuclei by benzo[a]pyrene in polychromatic erythrocytes mice. When each flavonoid was administered orally, together with intraperitoneally benzo[a]pyrene, most derivatives showed an effect. The data suggest that the 2,3-double bond 3,5,7-hydroxyl groups molecules may be essential to produce effects benzo[a]pyrene. Galangin, one active compounds, (-)-epicatechin, a weak one, mice order compare 3 different kinds carcinogens: ethyl methanesulfonate, 7,12-dimethylbenz[a]anthracene, adriamycin. Galangin stronger than (-)-epicatechin methanesulfonate 7,12-dimethylbenz[a]anthracene. However, there no significant adriamycin-induced both compounds. Our study indicates flavonoids are agents. Their apparently independent own clastogenic activities. Furthermore, activities do not apply universally all types genotoxic chemicals.
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