Human papilloma virus-dependent HMGA1 expression is a relevant step in cervical carcinogenesis.

摘要: HMGA1 is a member of small family architectural transcription factors involved in the coordinate assembly multiprotein complexes referred to as enhanceosomes. In addition their role cell proliferation, differentiation, and development, high-mobility group proteins A type (HMGA) members behave transforming protoncogenes either vitro or animal models. Recent reports indicated that might counteract p53 pathway provided an interesting hint on mechanisms determining HMGA's potential. expression deregulated very large array human tumors, including cervical cancer, but limited information available molecular leading deregulation cancer cells. Here, we report sustained by papilloma virus (HPV) E6/E7 demonstrated overexpression repression through RNA interference. Knocking down means interference, also showed it proliferation contributes inactivation this neoplasia. Finally, show necessary for full HPV18 E6 E7 oncoproteins thus establishing positive autoregulatory loop between HPV expression.