Expression of HMGI(Y) Proteins in Squamous Intraepithelial and Invasive Lesions of the Uterine Cervix

作者: Luigi Di Bonito , Alessandra Rustighi , Guidalberto Manfioletti , Vincenzo Giancotti , Fabrizio Zanconati

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摘要: The expression of nuclear proteins high mobility group (HMG) I and HMGY was investigated in intraepithelial invasive lesions the uterine cervix. Human carcinoma cell lines C-41, ME-180, CaSki were used for testing protein neoplastic cells from Morphological grading dysplasias (CIN 1, CIN 2, 3) carcinomas formalin-fixed paraffin-embedded samples parallels degree immunostaining obtained using a polyclonal antibody raised against amino-terminal region HMGI(Y) proteins. with compared that observed Ki-67, results similar. We suggest use clinical oncology as useful marker carcinomas.

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