The Role of the Mediators of Inflammation in Cancer Development

摘要: Epigenetic disorders such as point mutations in cellular tumor suppressor genes, DNA methylation and post-translational modifications are needed to transformation of normal cells into cancer cells. These events result alterations critical pathways responsible for maintaining the homeostasis, triggering an inflammatory response which can lead development cancer. The is a universal defense mechanism activated injury tissue, any nature, that involves both innate adaptive immune responses, through collective action variety soluble mediators. Many signaling several types cancer, linking chronic inflammation tumorigenesis process. Thus, Inflammatory responses play decisive roles at different stages development, including initiation, promotion, growth, invasion, metastasis, affecting also surveillance. Immune infiltrate tumors engage extensive dynamic crosstalk with cells, some molecular mediate this dialog have been revealed. A range mediators, cytokines, chemokines, free radicals, prostaglandins, growth transcription factors, microRNAs, enzymes as, cyclooxygenase matrix metalloproteinase, collectively acts create favorable microenvironment tumors. In review presented main mediators discussed likely mechanisms which, they interact each other condition