Methods for sequencing polymers using mass spectrometry

作者: Dale H. Patterson , George E. Tarr

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摘要: The methods and apparatus disclosed herein are useful for sequencing polymers using mass spectrometry. involve differing ratios of hydrolyzing agent to polymer disposed upon a reaction surface adapted use with spectrometer. further integrating data obtained from spectrometry analysis plurality series hydrolyzed fragments, optionally provide statistical interpretation paradigms computer software therefor. involves spectrometer sample holder, having thereon, which is adapting any sequencing.

参考文章(20)
Kouji Iwatani, Yuzo Nakagawa, Tetsuro Kadono, Sample holding element for mass spectrometer ,(1978)
Robert J. Cotter, Amina S. Woods, Wade Gibson, Protein Processing in Herpes Viruses Time-of-Flight Mass Spectrometry. ,vol. 204, pp. 194- ,(1994)
Yury Zlobinsky, Jules S. Lux, Unit for hydrolyzing amino-acid containing specimens ,(1990)
Rong Wang, Robert J. Cotter, James F. Meschia, Sangram S. Sisodia, Determination of the Cleavage Site of the Amyloid Precursor Protein by Plasma Desorption Mass Spectrometry Techniques in Protein Chemistry. pp. 505- 513 ,(1992) , 10.1016/B978-0-12-058756-8.50056-0
Eric R. Fought, Brian D. Andresem, Electrophoresis-mass spectrometry probe ,(1987)
Patricia J. Slininger, George Fanta, Enzyme immobilization with a hydrolyzed polysaccharide graft copolymer US Dept. of Agriculture. ,(1987)
Bernd Thiede, Brigitte Wittmann-Liebold, Michael Bienert, Eberhard Krause, MALDI-MS for C-terminal sequence determination of peptides and proteins degraded by carboxypeptidase Y and P FEBS Letters. ,vol. 357, pp. 65- 69 ,(1995) , 10.1016/0014-5793(94)01323-S
M. Karas, U. Bahr, A. Ingendoh, E. Nordhoff, B. Stahl, K. Strupat, F. Hillenkamp, Principles and applications of matrix-assisted UV-laser desorption/ionization mass spectrometry Analytica Chimica Acta. ,vol. 241, pp. 175- 185 ,(1990) , 10.1016/S0003-2670(00)83645-4
Horst Kagelmaker, Hans-Dieter Hunger, Monika Gratschus, Andre Rosenthal, Device for solid phase sequencing of nucleic acid fragments ,(1987)
Amina S. Woods, Robert J. Cotter, Motoi Yoshioka, Erika Büllesbach, Christian Schwabe, Enzymatic digestion on the sample foil as a method for sequence determination by plasma desorption mass spectrometry: the primary structure of porpoise relaxin International Journal of Mass Spectrometry and Ion Processes. ,vol. 111, pp. 77- 88 ,(1991) , 10.1016/0168-1176(91)85049-R