Personalized cancer vaccines and adoptive immune cell therapies

摘要: Cancer antigens containing mutations in an expressed gene of cancer cells from a patient are identified. Sequences obtained using parallel sequencing platform selected by comparing to the patient's normal genes or HLA-matched individual. further identifying HLA supertype and selecting for that supertype, sequences have particular amino acid at mutant position and/or corresponding wild-type effected gene. Peptides (i.e., mutations—once mutation is defined, what makes it immunogen its ability induce immune response) optionally tested binding patient. evaluated activating T (e.g., helper lymphocytes cytotoxic (CTL)) cell lines donor. The antigen(s) identified used prepare vaccine treat