Cinnamon treatment upregulates neuroprotective proteins Parkin and DJ-1 and protects dopaminergic neurons in a mouse model of Parkinson's disease.

摘要: Upregulation and/or maintenance of Parkinson’s disease (PD)-related beneficial proteins such as Parkin and DJ-1 in astrocytes during neurodegenerative insults may have therapeutic efficacy PD. Cinnamon is a commonly used natural spice flavoring material throughout the world. Here we explored novel use cinnamon upregulating protecting dopaminergic neurons MPTP mouse model Recently delineated that oral feeding (Cinnamonum verum) powder produces sodium benzoate (NaB) blood brain mice. Proinflammatory cytokine IL-1β decreased level Parkin/DJ-1 astrocytes. However, metabolite NaB abrogated IL-1β-induced loss these proteins. Inability TNF-α to produce nitric oxide (NO) decrease wild type (WT) astrocytes, failure reduce isolated from iNOS (−/−) mice, WT by NO donor DETA-NONOate suggest negative regulator Parkin/DJ-1. Furthermore, suppression expression reversal NaB-mediated protection indicate protects activated via suppressing iNOS. Similarly intoxication also increased vivo nigra. treatment MPTP-intoxicated mice with reduced protected These findings paralleled neuronal protection, normalized striatal neurotransmitters, improved motor functions results be for PD patients.