Are Infertile Men Less Healthy than Fertile Men? Results of a Prospective Case-Control Survey

摘要: Abstract Background An association between either subfertility or infertility and an elevated risk of certain male cancers has been previously reported. Nothing is known about abnormalities in general health conditions. Objective To assess whether men with factor (MFI) are overall less healthy than fertile men, regardless the reasons for infertility. Design, setting, participants From September 2006 to 2007, 344 consecutive European Caucasian MFI were enrolled this prospective case-controlled study. Patients compared a control group 293 age-comparable men. Infertile consecutively attending outpatient reproductive clinic at tertiary academic center. Fertile controls recruited by use advertisements posted within our hospital. Measurements Comorbidities patients objectively scored Charlson Comorbidity Index (CCI) according International Classification Diseases modified ninth version (ICD-9-CM) codes. Multivariate linear regression models tested predictors CCI score, as proxy status. Results According scores, infertile had significantly higher rate comorbidities (CCI: 0.33 [0.8] vs 0.14 [0.5]; p =0.365), while linearly increased age (β: 0.196; Conclusions These results show that accounts CCI, which may be considered reliable lower