The Plasmodium knowlesi MAHRP2 ortholog localizes to structures connecting Sinton Mulligan's clefts in the infected erythrocyte.
作者： Kwame Kumi Asare , Miako Sakaguchi , Amuza Byaruhanga Lucky , Masahito Asada , Shinya Miyazaki
DOI: 10.1016/J.PARINT.2018.04.005
关键词:
摘要: During development within the host erythrocyte malaria parasites generate nascent membranous structures which serve as a pathway for parasite protein transport to modify cell. The molecular basis of such is not well understood, particularly other than Plasmodium falciparum. To characterize structural trafficking in knowlesi-infected erythrocyte, we identified P. knowlesi ortholog MAHRP2, marker tether structure that connects falciparum-infected erythrocyte. We show PkMAHRP2 localizes on amorphous connect Sinton Mulligan's clefts (SMC) each and membrane. Three dimensional reconstruction revealed SMC plate-like with swollen ends, reminiscent morphology Golgi apparatus. PkMAHRP2-localized are possibly functionally equivalent falciparum structure. These findings suggest conservation ultrastructure between knowlesi.
nagasaki-u.ac.jp参考文章(53)
M. Aikawa, L. H. Miller, J. Rabbege, Caveola--vesicle complexes in the plasmalemma of erythrocytes infected by Plasmodium vivax and P cynomolgi. Unique structures related to Schüffner's dots. American Journal of Pathology. ,vol. 79, pp. 285- 300 ,(1975)
Eric Hanssen, Rachid Sougrat, Sarah Frankland, Samantha Deed, Nectarios Klonis, Jennifer Lippincott-Schwartz, Leann Tilley, Electron tomography of the Maurer's cleft organelles of Plasmodium falciparum‐infected erythrocytes reveals novel structural features Molecular Microbiology. ,vol. 67, pp. 703- 718 ,(2007) , 10.1111/J.1365-2958.2007.06063.X
Paul J. McMillan, Coralie Millet, Steven Batinovic, Mauro Maiorca, Eric Hanssen, Shannon Kenny, Rebecca A. Muhle, Martin Melcher, David A. Fidock, Joseph D. Smith, Matthew W. A. Dixon, Leann Tilley, Spatial and temporal mapping of the PfEMP1 export pathway in Plasmodium falciparum. Cellular Microbiology. ,vol. 15, pp. 1401- 1418 ,(2013) , 10.1111/CMI.12125
Matthias Marti, Robert T Good, Melanie Rug, Ellen Knuepfer, Alan F Cowman, Targeting Malaria Virulence and Remodeling Proteins to the Host Erythrocyte Science. ,vol. 306, pp. 1930- 1933 ,(2004) , 10.1126/SCIENCE.1102452
Ellen Knuepfer, Melanie Rug, Nectarios Klonis, Leann Tilley, Alan F. Cowman, Trafficking of the major virulence factor to the surface of transfected P falciparum–infected erythrocytes Blood. ,vol. 105, pp. 4078- 4087 ,(2005) , 10.1182/BLOOD-2004-12-4666
Sandra Nilsson, Davide Angeletti, Mats Wahlgren, Qijun Chen, Kirsten Moll, Plasmodium falciparum Antigen 332 Is a Resident Peripheral Membrane Protein of Maurer's Clefts PLoS ONE. ,vol. 7, pp. e46980- ,(2012) , 10.1371/JOURNAL.PONE.0046980
Xinhong Pei, Xiuli An, Xinhua Guo, Michal Tarnawski, Ross Coppel, Narla Mohandas, Structural and Functional Studies of Interaction between Plasmodium falciparum Knob-associated Histidine-rich Protein (KAHRP) and Erythrocyte Spectrin Journal of Biological Chemistry. ,vol. 280, pp. 31166- 31171 ,(2005) , 10.1074/JBC.M505298200
Kim-Sung Lee, Paul C. S. Divis, Siti Khatijah Zakaria, Asmad Matusop, Roynston A. Julin, David J. Conway, Janet Cox-Singh, Balbir Singh, Plasmodium knowlesi: reservoir hosts and tracking the emergence in humans and macaques. PLOS Pathogens. ,vol. 7, ,(2011) , 10.1371/JOURNAL.PPAT.1002015
Pierre-Yves Mantel, Anh N. Hoang, Ilana Goldowitz, Daria Potashnikova, Bashar Hamza, Ivan Vorobjev, Ionita Ghiran, Mehmet Toner, Daniel Irimia, Alexander R. Ivanov, Natasha Barteneva, Matthias Marti, Malaria-Infected Erythrocyte-Derived Microvesicles Mediate Cellular Communication within the Parasite Population and with the Host Immune System Cell Host & Microbe. ,vol. 13, pp. 521- 534 ,(2013) , 10.1016/J.CHOM.2013.04.009
Ritesh G. Menezes, Sadip Pant, Magdy A. Kharoshah, Subramanian Senthilkumaran, M. Arun, K.R. Nagesh, Nishanth B. Bhat, D.R. Mahadeshwara Prasad, Raj Kumar Karki, S.H. Subba, Abul Fazil, Autopsy discoveries of death from malaria Legal Medicine. ,vol. 14, pp. 111- 115 ,(2012) , 10.1016/J.LEGALMED.2012.01.007