Complex Interaction of the Sleep-Wake Cycle and Circadian Phase Modulates Mood in Healthy Subjects

摘要: Background: Several studies of healthy volunteers have revealed that subjective mood may vary with the duration prior wakefulness and time day. However, in these studies, effects extended circadian phase remained confounded, interaction 2 processes could not be assessed quantitatively. Methods: In present study, a total 24 young subjects (16 men, 8 women) lived on 30-hour sleep-wake schedule for 19 to 23 days or 28-hour 33 36 days; both schedules induced desynchrony between subjects' cycle their endogenous pacemaker. Subjective was by types visual analog scales, which were administered twice every hours 20 minutes, respectively, during all scheduled wake fulness episodes. A an interval elapsed since awakening attributed each data point, wake-dependent fluctuations assessed. Results: significant variation observed, but no reliable main effect found. statistically evident; when analysis restricted specific phases, improved, deteriorated, stable wakefulness. Conclusions: These results indicate that, subjects, is influenced complex nonadditive The nature this such moderate changes timing profound subsequent mood.