Antidepressant effects of the sleep/wake cycle phase advance. Preliminary report.

摘要: Five patients with endogenous depression were asked to participate in a phase-advance procedure consisting advancing by 5 h the time schedule of major external synchronizers such as light/dark, sleep/wake, meal and social activity cycles. Clinical biological parameters observed throughout this 2-week process which followed one night partial sleep deprivation. All improved deprivation four five showed continuing remission during process. The antidepressant effects are discussed light different chronobiological models for depression.