Fine-tuning of cortical progenitor proliferation by thalamic afferents.

摘要: During cerebral cortical cortex neurogenesis two major types of progenitors generate a variety morphologically and functionally diverse projection neurons destined for the different layers in non-gyrified mice. Radial glia cells (RGCs) undergo mitosis ventricular zone exhibit an apical-basal cell polarity, whereas non-polar intermediate progenitor (IPCs) divide basally subventricular (Franco Muller, 2013; Taverna et al., 2014). The contribution these subtypes to particular remains debated. Several lines evidence suggest that IPCs give rise majority neurons, while only 10–20 % are directly generated by apical 2013). generation excitatory follows temporal order with deep layer born first upper successively during later stages neurogenesis. Furthermore, symmetry mitotic division is instructive prospective fate daughter thus their laminar destination (Taverna Various intrinsic extrinsic cues have been identified regulate mode precursors. In addition intra-cortical control such as paracrine interactions between (North 2009) feedback signaling from post-mitotic plate (Seuntjens 2009), extra-cortical signals exerting over proliferation increasingly attracting attention. These include factors cortico-spinal fluid (Lehtinen Walsh, 2011) or invading glutamatergic (Teissier 2012). However, impact thalamo-cortical axons on formation largely unknown. Previous vitro studies suggested thalamic fibres cycle properties releasing soluble (Dehay 2001). turn, our data show contact-mediated regulation afferents (Figure 1) (Gerstmann 2015).