Implications thérapeutiques des mutations B-RAF dans le cancer colo-rectal
作者： A. Turpin , P. Zerbib , H. Lebrun
DOI: 10.1016/J.JCHIRV.2021.02.010
关键词:
摘要: Resume Les cancers colorectaux (CCR) avec une mutation du gene B-RAF ont un pronostic particulierement sombre. Dans cette situation, l’interet d’une chimiotherapie intensifiee associee a anti-VEGF (Vascular endothelial growth factor) en 1ere ligne de traitement des CCR metastatiques ete recemment remise question. Chez les patients presentant B-RAF, l’efficacite anti-EGFR (Epidermal Growth Factor Receptor) reste incertaine metastatique alors que celle est demontree. pistes therapeutiques inhibant l’activite inefficaces monotherapie, recu autorisation mise sur le marche association aux 2e metastatiques. L’immunotherapie donne resultats tres encourageants dans etude phase III recente chez MSI (Instabilite Microsatellites), et ce, quel soit statut B-RAF. Enfin, nouvelles ciblant autres proteines RAF d’autres recepteurs specifiques sont cours developpement. La chirurgie metastases hepatiques porteurs doit etre envisagee chaque fois possible, apres bilan exhaustif la recherche carcinose peritoneale distance, selon modalites techniques identiques celles sans
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