Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms

作者: Stephen T. Oh , Erin F. Simonds , Carol Jones , Matthew B. Hale , Yury Goltsev

DOI: 10.1182/BLOOD-2010-02-270108

关键词:

摘要: … LNK −/− mice exhibit an MPN phenotype, including an expanded hematopoietic stem cell compartment, megakaryocytic hyperplasia, splenomegaly, leukocytosis, and thrombocytosis. …

参考文章(21)
R A Mesa, A Tefferi, T S Lasho, D Loegering, R F McClure, H L Powell, N T Dai, D P Steensma, S H Kaufmann, Janus kinase 2 (V617F) mutation status, signal transducer and activator of transcription-3 phosphorylation and impaired neutrophil apoptosis in myelofibrosis with myeloid metaplasia. Leukemia. ,vol. 20, pp. 1800- 1808 ,(2006) , 10.1038/SJ.LEU.2404338
Robert Kralovics, Francesco Passamonti, Andreas S. Buser, Soon-Siong Teo, Ralph Tiedt, Jakob R. Passweg, Andre Tichelli, Mario Cazzola, Radek C. Skoda, A Gain-of-Function Mutation of JAK2 in Myeloproliferative Disorders The New England Journal of Medicine. ,vol. 352, pp. 1779- 1790 ,(2005) , 10.1056/NEJMOA051113
Jonathan M Irish, Randi Hovland, Peter O Krutzik, Omar D Perez, Øystein Bruserud, Bjørn T Gjertsen, Garry P Nolan, Single Cell Profiling of Potentiated Phospho-Protein Networks in Cancer Cells Cell. ,vol. 118, pp. 217- 228 ,(2004) , 10.1016/J.CELL.2004.06.028
Hitoshi Takizawa, Chiyomi Kubo-Akashi, Ikuo Nobuhisa, Sang-Mo Kwon, Masanori Iseki, Tetsuya Taga, Kiyoshi Takatsu, Satoshi Takaki, Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk. Blood. ,vol. 107, pp. 2968- 2975 ,(2006) , 10.1182/BLOOD-2005-05-2138
C. H. M. Jamieson, J. Gotlib, J. A. Durocher, M. P. Chao, M. R. Mariappan, M. Lay, C. Jones, J. L. Zehnder, S. L. Lilleberg, I. L. Weissman, The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 6224- 6229 ,(2006) , 10.1073/PNAS.0601462103
Chloé James, Valérie Ugo, Jean-Pierre Le Couédic, Judith Staerk, François Delhommeau, Catherine Lacout, Loïc Garçon, Hana Raslova, Roland Berger, Annelise Bennaceur-Griscelli, Jean Luc Villeval, Stefan N. Constantinescu, Nicole Casadevall, William Vainchenker, A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera Nature. ,vol. 434, pp. 1144- 1148 ,(2005) , 10.1038/NATURE03546
Linda M. Scott, Wei Tong, Ross L. Levine, Mike A. Scott, Philip A. Beer, Michael R. Stratton, P. Andrew Futreal, Wendy N. Erber, Mary Frances McMullin, Claire N. Harrison, Alan J. Warren, D. Gary Gilliland, Harvey F. Lodish, Anthony R. Green, JAK2 Exon 12 Mutations in Polycythemia Vera and Idiopathic Erythrocytosis The New England Journal of Medicine. ,vol. 356, pp. 459- 468 ,(2007) , 10.1056/NEJMOA065202
Ross L. Levine, Martha Wadleigh, Jan Cools, Benjamin L. Ebert, Gerlinde Wernig, Brian J.P. Huntly, Titus J. Boggon, Iwona Wlodarska, Jennifer J. Clark, Sandra Moore, Jennifer Adelsperger, Sumin Koo, Jeffrey C. Lee, Stacey Gabriel, Thomas Mercher, Alan D’Andrea, Stefan Fröhling, Konstanze Döhner, Peter Marynen, Peter Vandenberghe, Ruben A. Mesa, Ayalew Tefferi, James D. Griffin, Michael J. Eck, William R. Sellers, Matthew Meyerson, Todd R. Golub, Stephanie J. Lee, D. Gary Gilliland, Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell. ,vol. 7, pp. 387- 397 ,(2005) , 10.1016/J.CCR.2005.03.023
Luciana Teofili, Maurizio Martini, Tonia Cenci, Giovanna Petrucci, Lorenza Torti, Sergio Storti, Francesco Guidi, Giuseppe Leone, Luigi Maria Larocca, Different STAT-3 and STAT-5 phosphorylation discriminates among Ph-negative chronic myeloproliferative diseases and is independent of the V617F JAK-2 mutation Blood. ,vol. 110, pp. 354- 359 ,(2007) , 10.1182/BLOOD-2007-01-069237