Antifertility Effects of LHRH Agonists in the Male
作者： FERNAND LABRIE , ALAIN BÉLANGER , LIONEL CUSAN , CARL SEGUIN , GEORGES PELLETIER
DOI: 10.1002/J.1939-4640.1980.TB00034.X
关键词:
摘要: Acute or chronic treatment of adult male rats with luteinizing hormone-releasing hormone (LHRH) its agonist leads to a loss testicular LH and prolaction receptors accompanied by decreased testis seminal vesicle ventral prostate weight. The inhibition testosterone formation is due blockage the steroidogenic pathway at level 17-hydroxylase 1720-desmolase activities. desensitization pituitary responsiveness LHRH. Although inhibitory effects could be explained endogenous release induced LHRH secondary desentization LH-relasing peptides also exert direct on gonadotropin level. Moreover agonists bind specific receptor in interstitial cells. Chronic marked degenerative changes seminiferous tubules almost all showing signs histologic damage after 4 weeks treatment. Single administration an intranasal route normal men casuses transient plasma levels temporary diurnal cyclicity whereas preliminary data obtained patients cancer prostrate show both dihydrotestosterone levels. Such suggest potential use contraception for prostrate. (authors)
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