Male contraception with LHRH agonists

摘要: Stimulated by the unexplained lack of success LHRH and its agonists in treatment infertility men1, we investigated detail effect acute chronic administration these peptides on testicular functions experimental animals. We then made observation that short-term an agonist to adult male rats leads a loss LH prolactin receptors, as well decreased serum testosterone levels accompanied inhibition ventral prostate, seminal vesicle testis weight2–5. It is great interest that, among species so far studied, man most sensitive inhibitory with steroidogenesis5,6. In fact, while, rat, increases 5α-reductase activity formation 3α-androstanediol 5α-dihydrotestosterone, which can partially counteract production5,7, no such seen man, where androgen biosynthesis be completely inhibited medical castration thus achieved relatively easily secondary other than those related low circulating levels5,8,9.