No association between the metabotropic glutamate receptor type 3 gene (GRM3) and schizophrenia in a Japanese population
作者： Mamoru Tochigi , Motomu Suga , Jun Ohashi , Takeshi Otowa , Hidenori Yamasue
DOI: 10.1016/J.SCHRES.2006.07.008
关键词:
摘要: Several lines of evidence have suggested that the metabotropic glutamate receptor 3 (GRM3) gene is a candidate susceptibility for schizophrenia. To our knowledge, six studies investigated genetic association between GRM3 and schizophrenia, although results been quite controversial. In present study, we schizophrenia in 402 Japanese people by analyzing 10 single nucleotide polymorphisms (SNPs), including all SNPs showed significant previous studies. We observed no difference allelic frequencies or genotypic distributions controls patients. A permutation test global differences estimated haplotype Thus, study provides positive an population.
elsevier.com
sci-hub.se 参考文章(21)
Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Molecular Biology and Evolution. ,vol. 12, pp. 921- 927 ,(1995) , 10.1093/OXFORDJOURNALS.MOLBEV.A040269
Sylvia Bort Martí, Sven Cichon, Peter Propping, Markus Nöthen, Metabotropic glutamate receptor 3 (GRM3) gene variation is not associated with schizophrenia or bipolar affective disorder in the German population. American Journal of Medical Genetics. ,vol. 114, pp. 46- 50 ,(2002) , 10.1002/AJMG.1624
Jessica Moline, Del Miller, Jeffrey R. Bishop, Vicki L. Ellingrod, Association between the polymorphic GRM3 gene and negative symptom improvement during olanzapine treatment. Schizophrenia Research. ,vol. 77, pp. 253- 260 ,(2005) , 10.1016/J.SCHRES.2005.04.001
Yo Fujii, Hiroki Shibata, Rumiko Kikuta, Chieko Makino, Ayako Tani, Naotsugu Hirata, Atsushi Shibata, Hideaki Ninomiya, Nobutada Tashiro, Yasuyuki Fukumaki, Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia Psychiatric Genetics. ,vol. 13, pp. 71- 76 ,(2003) , 10.1097/01.YPG.0000056682.82896.B0
Ning Wang, Joshua M. Akey, Kun Zhang, Ranajit Chakraborty, Li Jin, Distribution of Recombination Crossovers and the Origin of Haplotype Blocks: The Interplay of Population History, Recombination, and Mutation American Journal of Human Genetics. ,vol. 71, pp. 1227- 1234 ,(2002) , 10.1086/344398
J.-P. Pin, R. Duvoisin, The metabotropic glutamate receptors: structure and functions. Neuropharmacology. ,vol. 34, pp. 1- 26 ,(1995) , 10.1016/0028-3908(94)00129-G
Stephen W Scherer, Robert M Duvoisin, Rainer Kuhn, Henry HQ Heng, Elena Belloni, Lap-Chee Tsui, None, Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q Genomics. ,vol. 31, pp. 230- 233 ,(1996) , 10.1006/GENO.1996.0036
Bita Moghaddam, Barbara W Adams, Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats Science. ,vol. 281, pp. 1349- 1352 ,(1998) , 10.1126/SCIENCE.281.5381.1349
Joseph T. Coyle, The glutamatergic dysfunction hypothesis for schizophrenia. Harvard Review of Psychiatry. ,vol. 3, pp. 241- 253 ,(1996) , 10.3109/10673229609017192
Qi Chen, Guang He, Qingying Chen, Shengnan Wu, Yifeng Xu, Guoyin Feng, Yucheng Li, Lijun Wang, Lin He, A case-control study of the relationship between the metabotropic glutamate receptor 3 gene and schizophrenia in the Chinese population Schizophrenia Research. ,vol. 73, pp. 21- 26 ,(2005) , 10.1016/J.SCHRES.2004.07.002