A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease
作者： A. Amin Al Olama , Z. Kote-Jarai , F. R. Schumacher , F. Wiklund , S. I. Berndt
DOI: 10.1093/HMG/DDS425
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摘要: Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third the heritability. To identify further susceptibility alleles, we conducted a meta-analysis four GWAS including 5953 cases aggressive PrCa and 11 463 controls (men without PrCa). We computed tests for approximately 2.6 million SNPs followed up most significant by genotyping 49 121 samples in 29 through international PRACTICAL BPC3 consortia. not only confirmed locus, rs11672691 on chromosome 19, also showed [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P 1.4 × 10(-8)]. This report describes variant which is PrCa, type poorer prognosis.
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