Folic Acid Supplements and Fortification Affect the Risk for Neural Tube Defects, Vascular Disease and Cancer: Evolving Science,

作者: Lynn B. Bailey , Gail C. Rampersaud , Gail P. A. Kauwell

DOI: 10.1093/JN/133.6.1961S

关键词:

摘要: Folic acid supplements reduce the risk of neural tube defects and may be associated with reduced for vascular disease cancer. Research data from both observational controlled intervention studies provide strong support existing public health policies related to folic defects. However, educational efforts promote daily intake by women reproductive age have not, in most cases, resulted increased supplement use. In contrast, food fortification appears a reduction United States Canada but is not practiced universally. The potential incidence severity cancer focus major research including ongoing studies.

参考文章(64)
Helga Refsum, PM Ueland, O Nygård, SE Vollset, Homocysteine and Cardiovascular Disease Annual Review of Medicine. ,vol. 49, pp. 31- 62 ,(1998) , 10.1146/ANNUREV.MED.49.1.31
K Khosraviani, H P Weir, P Hamilton, J Moorehead, K Williamson, Effect of folate supplementation on mucosal cell proliferation in high risk patients for colon cancer Gut. ,vol. 51, pp. 195- 199 ,(2002) , 10.1136/GUT.51.2.195
Margaret A Honein, Leonard J Paulozzi, TJ Mathews, J David Erickson, Lee-Yang C Wong, Impact of Folic Acid Fortification of the US Food Supply on the Occurrence of Neural Tube Defects JAMA. ,vol. 285, pp. 2981- 2986 ,(2001) , 10.1001/JAMA.285.23.2981
E. Giovannucci, M. J. Stampfer, G. A. Colditz, E. B. Rimm, D. Trichopoulos, B. A. Rosner, F. E. Speizer, W. C. Willett, Folate, Methionine, and Alcohol Intake and Risk of Colorectal Adenoma Journal of the National Cancer Institute. ,vol. 85, pp. 875- 884 ,(1993) , 10.1093/JNCI/85.11.875
George Christodoulakos, Costas Panoulis, Demetrios Rizos, Theodor Moustakarias, Iphigenia Phocas, George Creatsas, Homocysteine and folate levels in postmenopausal women Maturitas. ,vol. 39, pp. 161- 167 ,(2001) , 10.1016/S0378-5122(01)00207-9
Homocysteine Lowering Trialists' Collaboration, None, Lowering blood homocysteine with folic acid based supplements: Meta-analysis of randomised trials BMJ. ,vol. 316, pp. 894- 898 ,(1998) , 10.1136/BMJ.316.7135.894
Charles H. Halsted, Jesus A. Villanueva, Angela M. Devlin, Carol J. Chandler, Metabolic Interactions of Alcohol and Folate Journal of Nutrition. ,vol. 132, ,(2002) , 10.1093/JN/132.8.2367S
Enza Gucciardi, Donna L. Reynolds, Mary-Anne Pietrusiak, Jocelyn Rouleau, Incidence of neural tube defects in Ontario, 1986–1999 Canadian Medical Association Journal. ,vol. 167, pp. 237- 240 ,(2002)
Thomas E. Rohan, Meera G. Jain, Geoffrey R. Howe, Anthony B. Miller, Dietary Folate Consumption and Breast Cancer Risk Journal of the National Cancer Institute. ,vol. 92, pp. 266- 269 ,(2000) , 10.1093/JNCI/92.3.266
EGJ Vermeulen, CDA Stehouwer, JWR Twisk, M van den Berg, SC de Jong, AJC Mackaay, CMC van Campen, FC Visser, CAJM Jakobs, EJ Bulterijs, JA Rauwerda, Effect of homocysteine-lowering treatment with folic acid plus vitamin B6 on progression of subclinical atherosclerosis: a randomised, placebo-controlled trial The Lancet. ,vol. 355, pp. 517- 522 ,(2000) , 10.1016/S0140-6736(99)07391-2