A genetically determined incompatibility system between spermatozoa and eggs leading to embryonic death in mice.

摘要: The factors in the eggs of DDK mice and alien spermatozoa which are responsible for embryonic death females mated with males from other strains were subjected to genetic analysis. (1) In reciprocal backcrosses involving three inbred strains, survival was halved when F1 males, or two corresponding compared results matings males. (2) Reduction litter size semi-sterile found be caused by at morula-blastocyst pre-egg cylinder stages around time implantation. A common feature dead embryos a defect trophoblast formation. (3) Genetic analysis suggests that cytoplasmic factor egg both controlled autosomal genes located same locus closely linked. gene symbol om (ovum mutant) has been given mutant possessed strain, it is proposed interacts specifically sperm origin synthesize substance necessary