Role of Heparin on TNF-α and IL-6 Levels in Liver Regeneration after Partial Hepatic Resection
作者： H. Yuceturk , M.C. Yagmurdur , G. Gur , M. Demirbilek , B. Bilezikci
DOI: 10.1159/000101744
关键词:
摘要: Objectives: The aim of this study was to investigate the effect heparin on TNF-α and interleukin (IL)-6 levels complement system in liver regeneration a murine model. Materials Methods: 32 Wistar albino female rats weighing between 180 250 g were included study. divided into four groups as follows: group 1, treated with partial (50%) hepatectomy intravenous 1,000 IU/kg repeated daily doses; 2, sham operation 3, hepatectomy, 4 (controls), only operation. Before surgical intervention after general anesthetic had been administered all rats, blood taken from left ventricle each rat, sample assessed determine total hemolytic activity (CH50/ml). On 5th postoperative day, assess CH50 IL-6 via ELISA. Each rat then killed by decapitation which gravimetric analysis immunohistochemical staining for proliferating cell nuclear antigen (PCNA) performed. Results: Serum 1 4% compared 51% 3 (p = 0.01). serum level 43 pg/ml 86 0.002). 19 44 0.02). 2 0.005). According results analysis, mean rate 4.4% 22% 0.001). PCNA index values highest However, value lowest Conclusion: Because its anti-inflammatory action system, produced an unfavorable regeneration.
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