Recent advances in 2D-LC for bioanalysis

摘要: This article summarizes the most important developments in use of 2D-LC for bioanalysis last 5 years. While several interesting and powerful applications have been developed recently, this work has supported by continued, significant development theoretical concepts, instrument practical aspects method development. Some exciting focused on characterize proteins both as biotherapeutic drug substances, formulations. These materials are inherently complex, difficult to resolve chromatographically present problems that essentially unknown (e.g., aggregation) small molecule world, thus can be leveraged very effectively address these challenges.