Diverted organic synthesis (DOS): accessing a new, natural product inspired, neurotrophically active scaffold through an intramolecular Pauson–Khand reaction
作者： Goverdhan Mehta , Ramesh Samineni , Pabbaraja Srihari , R. Gajendra Reddy , Sumana Chakravarty
DOI: 10.1039/C2OB26107C
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摘要: Drawing inspiration from the impressive neurotrophic activity exhibited by natural product paecilomycine A, we have designed a new product-like scaffold employing an intramolecular Pauson–Khand reaction. Several compounds based on designer promising and are worthy of further biological evaluation. Our findings also highlight importance DOS strategy in creating useful therapeutical leads.
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