Enzyme synthesis in the regulation of hepatic `malic' enzyme activity

摘要: Abstract A homogeneous preparation of `malic' enzyme (EC 1.1.1.40) from livers thyroxine-treated rats was used to prepare in rabbits an antiserum the that reacts monospecifically with several physiological states. Changes activity resulting modification state animal are hence due altered amount protein. The has been precipitate out heat-treated supernatant preparations both adult and neonatal rats, a number conditions, had injected 30min earlier l-[4,5-3H]leucine. low incorporations radioactivity into immunoprecipitable have permitted qualitative conclusion changed arises mainly alterations rate synthesis. marked increase occurs naturally or as result thyroxine treatment weanling rat is likewise synthesis possibly associated concurrent diminished degradation.