Effects of capsaicin desensitization on nasal allergy-like symptoms and histamine release in the nose induced by toluene diisocyanate in guinea pigs.
作者： Y. Abe , N. Takeda , M. Irifune , S. Ogino , B. Kalubi
DOI: 10.3109/00016489209137463
关键词:
摘要: Intranasal application of toluene diisocyanate (TDI) induced nasal allergy-like symptoms sneezing and watery rhinorrhea decreased the histamine content mucosa in guinea pigs. However, animals pretreated with capsaicin (capsaicin desensitization) before sensitization TDI, were not induced. Capsaicin desensitization also inhibited release by TDI. These findings suggest that antidromic impulses capsaicin-sensitive sensory nerves stimulated TDI cause from mast cells mucosa, resulting discharge Thus neurogenic inflammation via an axon reflex nose may contribute to pathogenesis vasomotor rhinitis.
sci-hub.se 参考文章(23)
James I. Nagy, Capsaicin: A Chemical Probe for Sensory Neuron Mechanisms Springer, Boston, MA. pp. 185- 235 ,(1982) , 10.1007/978-1-4613-3452-1_4
B. Kalubi, M. Yamamo, K. Ohhata, T. Matsunaga, M. Tohyama, Presence of VIP fibers of sensory origin in the rat trachea. Brain Research. ,vol. 522, pp. 107- 111 ,(1990) , 10.1016/0006-8993(90)91583-3
S.H. Buck, P.P. Deshmukh, H.I. Yamamura, T.F. Burks, Thermal analgesia and substance P depletion induced by capsaicin in guinea-pigs Neuroscience. ,vol. 6, pp. 2217- 2222 ,(1981) , 10.1016/0306-4522(81)90009-9
J.A. Kiernan, Degranulation of mast cells in the trachea and bronchi of the rat following stimulation of the vagus nerve. International Archives of Allergy and Immunology. ,vol. 91, pp. 398- 402 ,(1990) , 10.1159/000235149
L. Lundblad, A. Saria, J. M. Lundberg, A. Änggård, Increased vascular permeability in rat nasal mucosa induced by substance P and stimulation of capsaicin-sensitive trigeminal neurons. Acta Oto-laryngologica. ,vol. 96, pp. 479- 484 ,(1983) , 10.3109/00016488309132734
J.M. Lundberg, T. H�kfelt, C.-R. Martling, A. Saria, C. Cuello, Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man. Cell and Tissue Research. ,vol. 235, pp. 251- 261 ,(1984) , 10.1007/BF00217848
N MYGIND, Mediators of nasal allergy. The Journal of Allergy and Clinical Immunology. ,vol. 70, pp. 149- 159 ,(1982) , 10.1016/0091-6749(82)90036-7
Atsushi Yamatodani, Hiroshi Fukuda, Hiroshi Wada, Toshinao Iwaeda, Takehiko Watanabe, High-performance liquid chromatographic determination of plasma and brain histamine without previous purification of biological samples: cation-exchange chromatography coupled with post-column derivatization fluorometry Journal of Chromatography A. ,vol. 344, pp. 115- 123 ,(1985) , 10.1016/S0378-4347(00)82012-5
D Sheppard, J E Thompson, L Scypinski, D Dusser, J A Nadel, D B Borson, Toluene diisocyanate increases airway responsiveness to substance P and decreases airway neutral endopeptidase. Journal of Clinical Investigation. ,vol. 81, pp. 1111- 1115 ,(1988) , 10.1172/JCI113424
Lars Lundblad, Jan M. Lundberg, Anders �ngg�rd, Local and systemic capsaicin pretreatment inhibits sneezing and the increase in nasal vascular permeability induced by certain chemical irritants Naunyn-Schmiedeberg's Archives of Pharmacology. ,vol. 326, pp. 254- 261 ,(1984) , 10.1007/BF00505327