Critique of the International Agency for Research on Cancer meta-analyses of the association of sunbed use with risk of cutaneous malignant melanoma

作者: William B. Grant

DOI: 10.4161/DERM.1.6.11461

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摘要: The International Agency for Research on Cancer (IARC) reported meta-analyses of the association cutaneous malignant melanoma (CMM), finding significant correlations with ever use sunbeds and first prior to age 35 years; it did not claim that associations showed causal links. However, some observational studies in meta-analysis included individuals UK skin phenotype at increased genetic risk CMM without adjustment phenotype. Treating five separately from other 14 corrected this oversight. In original study, summary relative (RR) respect sunbed was 1.15 (95% confidence interval [CI], 1.00-1.31). similar RR 1.20 CI, 1.03-1.38). 2.09 1.14-3.84), whereas 1.09 0.96-1.24). For years, IARC found a 1.75 1.35-2.36). This study plotted...

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