Gastric acidity influences the blood response to a beta-carotene dose in humans.

摘要: The effect of gastric acidity on the blood response to a single dose 120 mg beta-carotene in humans was investigated 12 normal subjects (5 women, 7 men) aged 23-68 y. Omeprazole used for d obliterate acid secretion and raise pH > 4.5. In crossover design, six were randomly assigned take with omeprazole either at beginning (day 9) or end 26) study. not altered by experimental order. Results from high-gastric-pH phase (ie, omeprazole) analyzed together compared results low-gastric-pH without omeprazole). increases serum concentrations both trans cis 6 24 h after significantly greater low (pH = 1.3 +/- 0.1, ie, than those high 6.4 0.3, omeprazole), P < 0.02. Similarly, administration, area under curve (trans plus beta-carotene) (6825 760 nmol.h/L) (3390 550 nmol.h/L), 0.002. investigations bacterial overgrowth, gelatin capsule disintegration isomeric profiles associated pH, we could identify factors explain differences observed curves between conditions. A suppressed intraluminal may have been due slower movement negatively charged micelles through unstirred water layer cell membrane.