Beta-carotene serum response in young and elderly females.

摘要: This study was designed to investigate the effects of aging and food intake on serum beta-carotene (BC) response curve in humans. Ten elderly (71 +/- 4 years) 17 young (28 7 healthy females were given 15 mg BC with a semi-solid test meal devoid vitamin A. All 10 subjects (control A) received 500 kcal while remaining B) 700 kcal. Subsequently, blood drawn hourly for 8 h again at 24 48 h. Serum carotenoids retinoids measured by HPLC triglycerides (TG) cholesterol enzymatic methods. Small intestinal transit time determined control group A breath hydrogen following ingestion lactulose (12 g) meal. The area under absorption (AUC) over first higher than either or B (P less 0.001). slopes TG curves significantly as compared A, but similar B. There positive correlation between ascending all groups AUC retinyl ester greater that slope this steeper 0.01) Intestinal groups. In subjects, larger appeared increase rate BC. These data indicate intact its conversion esters may be enhanced old age younger receiving same amount food. Age-related alterations enterocytes lumen could account phenomenon.