Prognostic and predictive value of intratumoral microvessels density in operable non-small-cell lung cancer.

摘要: Abstract Experimental evidence suggests that tumor growth and progression depend on angiogenesis. In a retrospective study we evaluated the relationship between angiogenesis survival in patients with NSCLC treated potentially curative surgery 1992 1997. The population consisted of 76 patients. An anti-CD34 monoclonal antibody was used to measure samples. Angiogenesis quantified terms microvessel count (MVC): each sample three most intense regions neovascularization were identified under low microscopic power. A ×250 field areas then counted highest fields recorded. Disease free (DFS) overall (OS) during follow up evaluated. Gender, age, stage, histologic type KI-67 other factors considered for analysis. median MVC our series 41.5. Among clinicopathologic parameters examined only one show significant association disease univariate analysis ( P =0.04). value is new indicator aggressiveness who underwent should be taken into consideration selecting adjuvant treatment.