Inverted Perceptual Judgment of Nociceptive Stimuli at Threshold Level following Inconsistent Cues

作者: Carmen Walter , Violeta Dimova , Julia Bu , Michael J. Parnham , Bruno G. Oertel

DOI: 10.1371/JOURNAL.PONE.0132069

关键词:

摘要: Objective: The perception of pain is susceptible to modulation by psychological and contextual factors. It has been shown that subjects judge noxious stimuli as more painful in a respective suggestive context, which disappears when the modifying context resolved. However, painfulness nociceptive stimulus exactly opposite direction cues never so far. Methods: Nociceptive (300 ms intranasal gaseous CO2) at individual threshold level were applied after visual cue announcing either "no pain", merely "stimulus", or "pain". Among level, other CO2 clearly below above randomly interspersed. These announced beforehand 12 with correct incorrect cues, i.e., non-painful equally often not painful. By contrast, subsequent group another subjects, always correctly respect evoked pain. Results: random announcement caused rate pain-threshold cue, "pain" significantly than vice versa (p < 10-4). absence incongruence between far-from-threshold stimuli, rated cued direction. Conclusions: present study revealed induction associations incongruent given message pain. We created unreliable whereby perceived suggested prior potentially judged versa. findings are consistent reported data on effects distrust cognitive responses.

参考文章(64)
Robert Sade, Nathan A Bostick, Dudley M Stewart, Mark A Levine, Judicial Affairs, Placebo use in clinical practice: report of the American Medical Association Council on Ethical and Judicial Affairs. Journal of Clinical Ethics. ,vol. 19, pp. 58- 61 ,(2008)
Ramona Kenntner-Mabiala, Paul Pauli, Affective modulation of brain potentials to painful and nonpainful stimuli. Psychophysiology. ,vol. 42, pp. 559- 567 ,(2005) , 10.1111/J.1469-8986.2005.00310.X
Alexander Ploghaus, Charvy Narain, Christian F. Beckmann, Stuart Clare, Susanna Bantick, Richard Wise, Paul M. Matthews, J. Nicholas P. Rawlins, Irene Tracey, Exacerbation of Pain by Anxiety Is Associated with Activity in a Hippocampal Network The Journal of Neuroscience. ,vol. 21, pp. 9896- 9903 ,(2001) , 10.1523/JNEUROSCI.21-24-09896.2001
Nicholas J. Voudouris, Connie L. Peck, Grahame Coleman, The role of conditioning and verbal expectancy in the placebo response Pain. ,vol. 43, pp. 121- 128 ,(1990) , 10.1016/0304-3959(90)90057-K
Jérémie Pariente, Peter White, Richard SJ Frackowiak, George Lewith, None, Expectancy and belief modulate the neuronal substrates of pain treated by acupuncture NeuroImage. ,vol. 25, pp. 1161- 1167 ,(2005) , 10.1016/J.NEUROIMAGE.2005.01.016
J. Lötsch, G. Ahne, J. Kunder, G. Kobal, T. Hummel, Factors affecting pain intensity in a pain model based upon tonic intranasal stimulation in humans Inflammation Research. ,vol. 47, pp. 446- 450 ,(1998) , 10.1007/S000110050359