The human mu-opioid receptor gene polymorphism 118A > G decreases cortical activation in response to specific nociceptive stimulation.

摘要: The authors sought to investigate the role of a common single nucleotide polymorphism in mu-opioid receptor gene (OPRM1) 118A > G for nociceptive sensory processing using event-related potentials (ERPs). Specific (carbon dioxide [CO-sub-2]: 40% volume-to-volume [vol/vol] and 60% vol/vol) nonnociceptive (hydrogen sulfide, 2 parts per million [ppm] 4 ppm) stimuli were applied nasal mucosa 45 volunteers. ERPs recorded from central lead. In this random sample, we found 37 noncarriers, 7 heterozygous carriers, 1 homozygous carrier variant OPRM1 118G allele (allelic frequency, 10%). Amplitudes ERP carriers were, on average, half as high those noncarriers. discriminant analysis, amplitude N1 response weaker was only parameter that discriminated statistically significantly between noncarriers allele. On basis N1-CO-sub-2 (40% vol/vol), correctly backclassified 68.6% cases or specifically modulates but not cortical activation.