Cell Cycle Arrest by Vpr in HIV-1 Virions and Insensitivity to Antiretroviral Agents

摘要: Expression of human immunodeficiency virus–type 1 (HIV-1) Vpr after productive infection T cells induces cell cycle arrest in the G2 phase cycle. In absence de novo expression, HIV-1 packaged into virions still induced arrest. Naturally noninfectious virus or rendered defective for by reverse transcriptase protease inhibitors were capable inducing Vpr-mediated These results suggest a model whereby both infectious and vivo, such as those surrounding follicular dendritic cells, participate immune suppression.