Endoplasmic reticulum stress sensitizes human esophageal cancer cell to radiation
作者： Xue-Li Pang
关键词:
摘要: AIM: To investigate the role of endoplasmic reticulum (ER) stress in cancer radiotherapy and its molecular mechanism. In order to test biological function autophagy, specific inhibitor or Beclin-1 knockdown was used inhibit effect on cell apoptosis thus detected. Additionally, involvement phos- phatidylinositol-3 kinase (PI3K)/Akt/mammalian target rapamycin (mTOR) pathway also detected by Western blotting. Finally, male nude mice inoculated subcutaneously with EC109 cells were confirm model observations.
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