Radiosensitization of tumor cells through endoplasmic reticulum stress induced by PEGylated nanogel containing gold nanoparticles
作者： Hironobu Yasui , Ryo Takeuchi , Masaki Nagane , Shunsuke Meike , Yoshinari Nakamura
DOI: 10.1016/J.CANLET.2014.02.005
关键词:
摘要: High atomic number molecules, such as gold and platinum, are known to enhance the biological effect of X-irradiation. This study was aimed determine radiosensitizing potential PEGylated nanogel containing nanoparticles (GNG) cellular mechanism involved. GNG pretreatment increased levels reproductive cell death apoptosis induced by accumulated in cytoplasm expression endoplasmic reticulum (ER) stress-related protein. suppressed repair capacity DNA after X-irradiation down-regulating repair-related proteins. Our results suggest that radiosensitized cells enhancing impairing via ER stress induction.
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sci-hub.se 参考文章(41)
Charles A. Belfi, Sosamma J. Berger, Satadal Chatterjee, Nathan A. Berger, Haruyo Hirota, Hypersensitivity to DNA Cross-linking Agents Associated with Up-Regulation of Glucose-regulated Stress Protein GRP78 Cancer Research. ,vol. 57, pp. 5112- 5116 ,(1997)
Amato J. Giaccia, Brent A. Rupnow, Susan J. Knox, Rodolfo M. Alarcon, Albert D. Murtha, Direct Evidence That Apoptosis Enhances Tumor Responses to Fractionated Radiotherapy Cancer Research. ,vol. 58, pp. 1779- 1784 ,(1998)
Alice X. Meng, Farid Jalali, Andrew Cuddihy, Norman Chan, Ranjit S. Bindra, Peter M. Glazer, Robert G. Bristow, Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells. Radiotherapy and Oncology. ,vol. 76, pp. 168- 176 ,(2005) , 10.1016/J.RADONC.2005.06.025
Thomas Helleday, Eva Petermann, Cecilia Lundin, Ben Hodgson, Ricky A. Sharma, DNA repair pathways as targets for cancer therapy Nature Reviews Cancer. ,vol. 8, pp. 193- 204 ,(2008) , 10.1038/NRC2342
Boris Zhivotovsky, Bertrand Joseph, Sten Orrenius, Tumor Radiosensitivity and Apoptosis Experimental Cell Research. ,vol. 248, pp. 10- 17 ,(1999) , 10.1006/EXCR.1999.4452
Meng-Ya Chang, Ai-Li Shiau, Yu-Hung Chen, Chih-Jui Chang, Helen H-W Chen, Chao-Liang Wu, Increased apoptotic potential and dose-enhancing effect of gold nanoparticles in combination with single-dose clinical electron beams on tumor-bearing mice Cancer Science. ,vol. 99, pp. 1479- 1484 ,(2008) , 10.1111/J.1349-7006.2008.00827.X
Emmy P. Rogakou, Duane R. Pilch, Ann H. Orr, Vessela S. Ivanova, William M. Bonner, DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139 Journal of Biological Chemistry. ,vol. 273, pp. 5858- 5868 ,(1998) , 10.1074/JBC.273.10.5858
Motoi Oishi, Yukio Nagasaki, Synthesis, characterization, and biomedical applications of core–shell-type stimuli-responsive nanogels – Nanogel composed of poly[2-(N,N-diethylamino)ethyl methacrylate] core and PEG tethered chains Reactive & Functional Polymers. ,vol. 67, pp. 1311- 1329 ,(2007) , 10.1016/J.REACTFUNCTPOLYM.2007.07.009
Ravinder Nath, Paul Bongiorni, Peter I Rossi, Sara Rockwell, None, Enhanced IUdR radiosensitization by 241Am photons relative to 226Ra and 125I photons at 0.72 Gy/hr International Journal of Radiation Oncology*Biology*Physics. ,vol. 18, pp. 1377- 1385 ,(1990) , 10.1016/0360-3016(90)90311-7
Xue-Li Pang, Endoplasmic reticulum stress sensitizes human esophageal cancer cell to radiation World Journal of Gastroenterology. ,vol. 19, pp. 1736- 1748 ,(2013) , 10.3748/WJG.V19.I11.1736