Immunosuppressive Biological Mechanisms Support Reassessment of Use of the Injectable Contraceptive Medroxyprogesterone Acetate
作者： Janet P. Hapgood
DOI: 10.1210/EN.2013-1066
关键词:
摘要: Whether or not hormonal contraceptives increase the risk of HIV-1 acquisition and transmission AIDS disease progression is a crucial public health question. There good reason to focus in particular on effects injectable contraceptive medroxyprogesterone acetate (MPA) which administered as 150-mg 3-monthly intramuscular injection referred Depo-Provera depot MPA (DMPA). DMPA used by over 50 million women worldwide particularly areas with high prevalence. The central hypothesis examined this paper that more so than physiological concentrations progesterone (P4) likely repress immune function at doses within range found serum users due its potent glucocorticoid-like immunosuppressive properties could influence pathogenicity infectious diseases. Taken together key results from study provide important insights into biological mechanisms primary human cells are be highly significant for infectivity progression. motivation further research
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endojournals.org参考文章(21)
Catherine A. Blish, Jared M. Baeten, Hormonal Contraception and HIV-1 Transmission American Journal of Reproductive Immunology. ,vol. 65, pp. 302- 307 ,(2011) , 10.1111/J.1600-0897.2010.00930.X
Christoph M. Bamberger, Tobias Else, Ana-Maria Bamberger, Frank Ulrich Beil, Heinrich M. Schulte, Dissociative glucocorticoid activity of medroxyprogesterone acetate in normal human lymphocytes The Journal of Clinical Endocrinology and Metabolism. ,vol. 84, pp. 4055- 4061 ,(1999) , 10.1210/JCEM.84.11.6091
Ronald H Gray, Use of hormonal contraceptives and risk of HIV-1 transmission Lancet Infectious Diseases. ,vol. 12, pp. 507- ,(2012) , 10.1016/S1473-3099(12)70111-1
Charles S Morrison, Kavita Nanda, Hormonal contraception and HIV: an unanswered question Lancet Infectious Diseases. ,vol. 12, pp. 2- 3 ,(2012) , 10.1016/S1473-3099(11)70254-7
Charles S. Morrison, Stephanie Skoler-Karpoff, Cynthia Kwok, Pai-Lien Chen, Janneke van de Wijgert, Marlena Gehret-Plagianos, Smruti Patel, Khatija Ahmed, Gita Ramjee, Barbara Friedland, Pekka Lahteenmaki, Hormonal contraception and the risk of HIV acquisition among women in South Africa AIDS. ,vol. 26, pp. 497- 504 ,(2012) , 10.1097/QAD.0B013E32834FA13D
Katharina Ronacher, Katie Hadley, Chanel Avenant, Elisabeth Stubsrud, S. Stoney Simons, Ann Louw, Janet P. Hapgood, Ligand-selective transactivation and transrepression via the glucocorticoid receptor: Role of cofactor interaction Molecular and Cellular Endocrinology. ,vol. 299, pp. 219- 231 ,(2009) , 10.1016/J.MCE.2008.10.008
Janet Patricia Hapgood, Michele Tomasicchio, Modulation of HIV-1 virulence via the host glucocorticoid receptor: towards further understanding the molecular mechanisms of HIV-1 pathogenesis. Archives of Virology. ,vol. 155, pp. 1009- 1019 ,(2010) , 10.1007/S00705-010-0678-0
Dominique Koubovec, Wim Vanden Berghe, Linda Vermeulen, Guy Haegeman, Janet Patricia Hapgood, Medroxyprogesterone acetate downregulates cytokine gene expression in mouse fibroblast cells. Molecular and Cellular Endocrinology. ,vol. 221, pp. 75- 85 ,(2004) , 10.1016/J.MCE.2004.03.006
Frank Z. Stanczyk, Janet P. Hapgood, Sharon Winer, Daniel R. Mishell, Progestogens used in postmenopausal hormone therapy: differences in their pharmacological properties, intracellular actions, and clinical effects. Endocrine Reviews. ,vol. 34, pp. 171- 208 ,(2013) , 10.1210/ER.2012-1008
Anrudh K. Jain, Hormonal contraception and HIV acquisition risk: implications for individual users and public policies Contraception. ,vol. 86, pp. 645- 652 ,(2012) , 10.1016/J.CONTRACEPTION.2012.03.008