Vegetable Oil Intake and Breast Cancer Risk: a Meta-analysis

摘要: Background Total fat intake may be associated with increased risk of breast cancer, and fish oil has been suggested as a protection factor to cancer. But the effect vegetable oils is inconclusive. We aimed investigate association high consumption cancer risk, evaluated their dose-response relationship. Design systematically searched MEDLINE, EMBASE, Cochrane databases, CNKI updated December 2014, identified all observational studies providing quantitative estimates between different consumption. Fixed or random models were used estimate summary odds ratios for highest vs. lowest intake, relationship was assessed by restricted cubic spline model generalized least-squares trend (GLST) model. Results Five prospective cohort 11 retrospective case-control studies, involving 11,161 events from more than 150,000 females, met inclusion criteria. Compared consumption, higher didn't pooled OR 0.88 (95% CIs:0.77-1.01), result dose- response analyses show significant positive negative on each 10 g oil/day increment (OR=0.98, 95% CIs: 0.95-1.01). In subgroup analyses, might impact females strata BMI. Higher olive showed protective against 0.74 0.60-0.92), which not among three studies. Conclusions This meta-analyses that Olive occurrence whole. Recall bias imbalance in study location subtypes shouldn't ignored. More are required confirm interaction population various characteristic, further subtype