Effect of vascular endothelial growth factor-induced angiogenesis on TRAM flap harvesting after abdominoplasty.

摘要: In this study, the effect of intramuscular injection human vascular endothelial growth factor (hVEGF) on neovascularization following abdominoplasty was investigated. Twenty-four Sprague-Dawley rats were divided into four groups (n = 6). Two control and two experimental established. Abdominoplasty performed in all rats, with division perforator vessels. groups, normal saline injected rectus abdominis muscle, 100 microg VEGF muscle. A transverse musculocutaneous (TRAM) flap harvested day 20 40 both groups. The range viability TRAM was, respectively, 0 to percent (mean, 6.7 percent) 25 14.2 short-term long-term (no injected). study (VEGF) group demonstrated a 50 80 70 for 85 72.5 group. No wound infection documented, there no deaths during period. There statistically significant difference between divisions (p < 0.01); however, differences observed 0.01). authors concluded that after improved percentage viability. This method delay/revascularization could be used difficult problem high-risk patients.