KINETICS OF PROCALCITONIN IN IATROGENIC SEPSIS

摘要: Sir: We report a rare case of iatrogenic sepsis in which the kinetics procalcitonin (PCT) after injection gram-negative bacteria are described for first time. Since original publication The Lancet [1] there has been growing evidence that elevated PCT levels absence hypercalcitoninemia specific markers severity host response patients with bacterial or fungal infection [2-4]. Rapid increase within 2-4 h intravenous endotoxin at dose 4 mg/kg BW reported normal subjects by Dandona et al. [5]. In this study TNFct increased 1 and peaked 2 h, IL-6 3 h. Baseline were reached again 6 8 respectively, whereas maintaining plateau through 8-24 A 76-year-old woman peripheral arterial occlusive disease felt well before she received an infusion deproteinized hemodialysate calf blood outpatient practice. rationale therapy improvement support remains matter discussion. One half fluid had given days earlier. remaining half, stored room temperature 48 was administered on admission day. This procedure is clearly not recommended manufacturer. Immediately patient developed dizziness, restlessness, tachyarrhythmia absoluta (185/min) painful myalgias transferred to our hospital ambulance. Cerebral mesenteric embolism initially suspected. However, fever up 40.3 °C 9 disseminated intravascular coagulation developed. Initial leucopenia (2,300/mm 3) followed leucocytosis (28,300/mm 27 Microbiologic culture incriminated specimen revealed severe contamination Acinetobacter baumanii. treated i.v. antibiotics (piperacillin, gentamycin, oxacillin), oxygen 300