Estramustine induces disorganization of microtubules, perinuclear retraction of vimentin and endoplasmatic reticulum, and inhibits cell migration
作者： Mikael Rutberg , Margareta Wallin
DOI: 10.1016/S0065-1281(11)80254-0
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摘要: Summary The effects of the mitotic inhibitor estramustine on cytoskeleton DU 145 and AG 1518 cells were studied. Estramustine caused a partial disassembly microtubules withdrawal from cell periphery, disorganized delayed regrowth disassembled microtubules. It also induced spheroid cellular morphology affected adhesion survival. Sometimes seemed to be organized several microtubule-organizing centers. cytoskeleton-dependent migration was inhibited in presence microtubule-interacting vimentin endoplasmatic reticulum retracted perinuclear area. Our results show that not only complete microtubules, but disturbances microtubule network can have dramatic microtubule-dependent processes localization organelles. These could importance treatment orostatic carcinoma with estramustine.
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sci-hub.se 参考文章(39)
Martin Kanje, Anders Edström, Margareta Wallin, Per Ekström, Johanna Deinum, Beryl Hartley-Asp, Effect of Estramustine Phosphate on the Assembly of Isolated Bovine Brain Microtubules and Fast Axonal Transport in the Frog Sciatic Nerve Cancer Research. ,vol. 45, pp. 2234- 2239 ,(1985)
Kenneth D. Tew, Ann L. Wang, Gregg Kyle, Alfred Johnson, Carbamoylation of Glutathione Reductase and Changes in Cellular and Chromosome Morphology in a Rat Cell Line Resistant to Nitrogen Mustards but Collaterally Sensitive to Nitrosoureas Cancer Research. ,vol. 45, pp. 2326- 2333 ,(1985)
Åke Pousette, Jan-Åke Gustafsson, Björn Forsgren, Bertil Högberg, Binding Characteristics of a Major Protein in Rat Ventral Prostate Cytosol That Interacts with Estramustine, a Nitrogen Mustard Derivative of 17β-Estradiol Cancer Research. ,vol. 39, pp. 5155- 5164 ,(1979)
Björn Dahllöf, Fernando Cabral, Anita Billström, Beryl Hartley-Asp, Estramustine depolymerizes microtubules by binding to tubulin Cancer Research. ,vol. 53, pp. 4573- 4581 ,(1993)
D. Thrower, M.A. Jordan, L. Wilson, Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis. Journal of Cell Science. ,vol. 102, pp. 401- 416 ,(1992) , 10.1242/JCS.102.3.401
Roy G. Burns, Stoichiometry of estramustine phosphate binding to MAP2 measured by the disassembly of chick brain MAP2: Tubulin microtubules Cell Motility and the Cytoskeleton. ,vol. 17, pp. 167- 173 ,(1990) , 10.1002/CM.970170304
Susan Band Horwitz, Mechanism of action of taxol Trends in Pharmacological Sciences. ,vol. 13, pp. 134- 136 ,(1992) , 10.1016/0165-6147(92)90048-B
Mary Ann Jordan, Leslie Wilson, Kinetic analysis of tubulin exchange at microtubule ends at low vinblastine concentrations. Biochemistry. ,vol. 29, pp. 2730- 2739 ,(1990) , 10.1021/BI00463A016
Bo Fridén, Margareta Wallin, Johanna Deinum, Veena Prasad, Richard Luduena, Effect of estramustine phosphate on the assembly of trypsin-treated microtubules and microtubules reconstituted from purified tubulin with either tau, MAP2, or the tubulin-binding fragment of MAP2 Archives of Biochemistry and Biophysics. ,vol. 257, pp. 123- 130 ,(1987) , 10.1016/0003-9861(87)90550-9
R GOLDMAN, E FOLLETT, The structure of the major cell processes of isolated BHK21 fibroblasts Experimental Cell Research. ,vol. 57, pp. 263- 276 ,(1969) , 10.1016/0014-4827(69)90150-5