IL-10 blocks the development of resistance to re-infection with Schistosoma mansoni.

摘要: Despite effective chemotherapy to treat schistosome infections, re-infection rates are extremely high. Resistance reinfection can develop, however it typically takes several years following numerous rounds of treatment and re-infection, often develops in only a small cohort individuals. Using well-established highly permissive mouse model, we investigated whether immunoregulatory mechanisms influence the development resistance. Following Praziquantel (PZQ) S. mansoni infected mice observed significant mixed anti-worm response, characterized by Th1, Th2 Th17 responses. elevated response PBMC's, liver, spleen mesenteric lymph nodes, this did not confer any protection from secondary challenge infection. Because increase IL-10-producing CD4+CD44+CD25+GITR+ lymphocytes was observed, hypothesised that IL-10 obstructing Blockade combined with PZQ afforded greater than 50% reduction parasite establishment during reinfection, compared alone, indicating obstructs acquired Markedly enhanced responses, worm-specific IgG1, IgG2b IgE circulating eosinophils protection. This study demonstrates blocking signalling facilitate protective immunity provide strategy protect against mansoni.