Blocking the receptor for IL-10 improves antimycobacterial chemotherapy and vaccination.

摘要: Novel approaches are required for the prevention and therapy of mycobacterial infections since only vaccine in use, bacillus Calmette-Guerin, is poorly effective chemotherapy long often ineffective sterilizing infection. We used a mouse model Mycobacterium avium infection to address usefulness mAb able block IL-10R both treatment primary conventional multidrug subunit vaccination. Treatment infected mice with this during entire period experimental had little impact on course M. infection, slight improvement resistance observed liver spleen at day 30 which was associated increased macrophage activation priming CD4+ T cells IFN-γ production. Administration later no effect its course, but improved effectiveness when latter started chronic phase Also, anti-IL-10R acted as an adjuvant induction protective immunity upon vaccination preparation.